To maximize yield per unit area, modern global agricultural systems rely heavily on the intensive application of fertilizers, pesticides, and herbicides. For resolving these problems in crop production nanofertilizers, are an effective tool. Therefore, the experiment was carried out to evaluate the effectiveness of combined applications of conventional fertilizers and nanofertilizers on qualitative characters as well as garlic bulb yield. The results exhibited that application of 80 percent RDF + 3 sprays of nano NPK + 3 sprays of nano Zn and nano Fe resulted in enhancing the overall nutritional quality as well as yield of garlic. Thus, applying nanofertilizers via foliar applications and in conjunction with conventional fertilizers as soil applications resulted in reducing of 20 percent of synthetic fertilizers while simultaneously maintaining the quality as well as yield. Further research and field trials on nanofertilizers—both alone and in combination with conventional fertilizers—are necessary to fully assess their benefits and long-term effects. These studies could pave the way for more efficient and environmentally sustainable crop nutrition.